The serif vs. sans-serif debate centers on readability. Serifs may guide the eye in print, while sans-serifs tend to perform better on screens. Factors like letter case, alignment, line length, and leading all affect how easily text can be read.

Try to avoid all caps for large blocks of text and aim for 60–72 characters per line. Ranged-left text (Left aligned text) is generally more readable than justified or ranged-right, but design choices should always reflect the type of content and context.