To configure tooltips in Tippy.js, you use a range of options that control their appearance and behavior. The content option specifies the text or HTML displayed inside the tooltip. This is the main message you want users to see. The placement option determines where the tooltip appears in relation to the target element, such as above, below, to the left, or to the right. The delay option allows you to set how long to wait before showing or hiding the tooltip, using an array with the first value for the show delay and the second for the hide delay. The arrow option enables or disables the arrow pointer on the tooltip, helping to visually connect the tooltip to its target. By combining these options, you can tailor tooltips to suit different interface elements and user experience needs.